CHROMOSOMAL BASIS OF INHERITANCE

CHAPTER 15: CHROMOSOMAL BASIS OF INHERITANCE

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1. According to Morgan’s terminology, what is the difference between wild type and mutant phenotype?

2. Look at Figure 15.4. How did Morgan figure out that the gene for eye color is on the X chromosome? Explain the F1 cross and what was produced in F2.

3. What are sex-linked genes?

4. In mammals (and fruit flies) are males or females the heterogametic sex? Is this the case for all species?

5. Draw a Punnett square to show how sex is determined in humans (XX x XY). This also explains why we have about a 50:50 sex ratio.

6. Which chromosome carries more genes, X or Y?

Are there genes on the Y chromosome that are important for all humans? What type of genes are found on the Y chromosome?

7. Why are men more likely than women to get a sex-linked disorder?

8. Can a man pass on a sex-linked disorder to his sons? Explain.

9. Define:

Non-disjunction

When can non-disjunction occur?

Aneuploidy

10. When aneuploidy occurs, what usually happens to the embryo?

11. Explain what happens to the DNA when the following occur:

Deletion

Duplication

Inversion

Translocation

12. What causes Down syndrome?