Directions: Answer the following questions on a separate document. Explain how you reached the answer or show your work if a mathematical calculation…

Directions: Answer the following questions on a separate document. Explain how you reached the answer or show your work if a mathematical calculation is needed, or both. Please showing your work in a MS-Excel spreadsheet.1. Which of the following statements about dividend policies is CORRECT? a. Modigliani and Miller argue that investors prefer dividends to capital gains because dividends are more certain than capital gains. They call this the ―bird-in-the hand‖ effect. b. One reason that companies tend to avoid stock repurchases is that dividend payments are taxed at a lower rate than gains on stock repurchases. c. One advantage of dividend reinvestment plans is that they allow shareholders to avoid paying taxes on the dividends that they choose to reinvest. d. One key advantage of a residual dividend policy is that it enables a company to follow a stable dividend policy. e. The clientele effect suggests that companies should follow a stable dividend policy. 2. Which of the following statements is CORRECT? a. One disadvantage of dividend reinvestment plans is that they increase transactions costs for investors who want to increase their ownership in the company. b. One advantage of dividend reinvestment plans is that they enable investors to postpone paying taxes on the dividends credited to their account. c. Stock repurchases can be used by a firm that wants to increase its debt ratio. d. Stock repurchases make sense if a company expects to have a lot of profitable new projects to fund over the next few years, provided investors are aware of these investment opportunities. e. One advantage of an open market dividend reinvestment plan is that it provides new equity capital and increases the shares outstanding. 3. Which of the following statements is CORRECT? a. When firms are deciding on the size of stock splits—say whether to declare a 2-for-1 split or a 3-for-1 split, it is best to declare the smaller one, in this case the 2-for-1 split, because then the after-split price will be higher than if the 3-for-1 split had been used. b. Back before the SEC was created in the 1930s, companies would declare reverse splits in order to boost their stock prices. However, this was determined to be a deceptive practice, and it is illegal today. c. Stock splits create more administrative problems for investors than stock dividends, especially determining the tax basis of their shares when they decide to sell them, so today stock dividends are used far more often than stock splits. d. When a company declares a stock split, the price of the stock typically declines—by about 50% after a 2-for-1 split—and this necessarily reduces the total market value of the equity. e. If a firm’s stock price is quite high relative to most stocks—say $500 per share—then it can declare a stock split of say 10-for-1 so as to bring the price down to something close to $50. Moreover, if the price is relatively low—say $2 per share—then it can declare a ―reverse split‖ of say 1-for-25 so as to bring the price up to somewhere around $50 per share. 4. Which of the following statements is CORRECT? a. If a firm follows the residual dividend policy, then a sudden increase in the number of profitable projects is likely to reduce the firm’s dividend payout. b. The clientele effect can explain why so many firms change their dividend policies so often. c. One advantage of adopting the residual dividend policy is that this policy makes it easier for corporations to develop a specific and well-identified dividend clientele. d. New-stock dividend reinvestment plans are similar to stock dividends because they both increase the number of shares outstanding but don’t change the firm’s total amount of book equity. e. Investors who receive stock dividends must pay taxes on the value of the new shares in the year the stock dividends are received. 5. DeAngelo Corp.’s projected net income is $150.0 million, its target capital structure is 25% debt and 75% equity, and its target payout ratio is 65%. DeAngelo has more positive NPV projects than it can finance without issuing new stock, but its board of directors had decreed that it cannot issue any new shares in the foreseeable future. The CFO now wants to determine how the maximum capital budget would be affected by changes in capital structure policy and/or the target dividend payout policy. Versus the current policy, how much larger could the capital budget be if (1) the target debt ratio were raised to 75%, other things held constant, (2) the target payout ratio were lowered to 20%, other things held constant, and (3) the debt ratio and payout were both changed by the indicated amounts. Increase in Capital Budget Increase Debt Lower Payout Do Both to 75% to 20%___________________ a. $114.0 $73.3 $333.9 b. $120.0 $77.2 $351.5 c. $126.4 $81.2 $370.0 d. $133.0 $85.5 $389.5 e. $140.0 $90.0 $410.0Answer is 1/correct answer is E.2/correct answer is C.3/ CORRECT ANSWER IS E.4/correct answer is A.5/correct answer is E.

 

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Community & Public Health due today

10 Essential Services of Public Health

Public health services are divided into four major categories and 10 specific services.

  • Complete the worksheet, to access, click here:
    • Describe the four major categories and 10 essential services of public health and find a real-life example of each service.
    • Provide a definition for each of the four categories and 10 essential services of public health listed on the worksheet. (The definition should be approximately three to four sentences each, written in your own words.)
    • Identify via an internet search a real-life example of each of the 10 essential services. (The example may be a program, initiative, or service of a government agency, community service agency, non-profit organization, or community action group.)
    • Provide a description and brief discussion of how each example relates to the definition of the essential service.
    • Include a link to the website where you found information about each example.
  • Add a title page with the following:
    • Title of assignment
    • Student’s name
    • Course name and number
    • Instructor’s name
    • Date submitted
    • Include a reference page formatted according to APA style as outlined in the Ashford Writing Center.

NOTE: For the four categories of services, you only need to include a definition; you do not need to provide an example of the categories. All information you include on the worksheet must be in your own words and cited appropriately in APA style as outlined by the Ashford Writing Center.  No quotes or copy-pasted material will be accepted.

 

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Instructions: What is the difference between scaffolding and docking functions?

Instructions: What is the difference between scaffolding and docking functions? Support your answer with by specifically citing experimental data.This is based upon Bardwell, et al, 2001 (posted as an attached file). Be specific as possible in your answers. When asked to cite experimental data you must report specifically on experimental data reported in the paper and indicate where I the paper you obtained the data (e.g. Figure 1). Part A: Short answer/definition questionsAnswer 10 of the following 14 questions.1. What are two different mechanisms of target activation by MAPKs?2. What are the four defined MAPK signaling pathways in yeast?3. What is an ortholog? Give a specific example of an ortholog of yeast Ste7.4. Explain why yeast may serve as a model organism for studies of mammalian MAPKs.5. What is a combinatorial library? 6. Explain the limitation of using the consensus sequence, -(Ser/Thr)-Pro-, as a determinant of kinase specificity.7. Why is the high affinity binding site (docking site) under investigation unlikely to represent a prototypical enzyme-substrate interaction site?8. Typically, non catalytic domains are not well conserved relative to catalytic domains across species. However, the docking site is unique in that it is a non catalytic domain and conserved across many MEK orthologs. Speculate on why this domain, in contrast to the majority of residues in the non catalytic domain, is conserved.9. Referring to figure 2A, why were Kss1 and Hog1 radiolabeled?10. Referring to figure 2A, why did the authors include the GST alone condition?11. The MEK2-ERK2 interaction had a Kd of ~ 9µM. Define Kd and describe what 9uM is specifically referring to.12. What is lacZ? How is it used as a reporter?13. What is a halo assay?14. What is an adaptor protein?Part B: Long answer questionsAnswer 10 of the following 16 questions.1. After figure 2 the authors conclude that the docking site is sufficient for binding. What do they mean by this? Is the docking site the only site on Ste7 or MEK1 that interacts with their targets? Cite specific experimental data to support your conclusions.2. The Ste7-ERK1 interaction had a Kd of ~1µM. Explain why this is surprising. Would you expect the Kd of the Ste7-ERK2 interaction to be higher or lower then Ste7-JNK1? Support your answer by citing experimental data.3. What is an IC50 value? How might the IC50 values derived from figure 5 be related to the Kd values determined earlier in the paper?4. Using figure 1 and figure 4, propose a MEK1 mutant with an alteration of TWO and only TWO specific amino acids that would result in the largest decrease in ERK2 binding relative to WT.5. Which protein would you predict to have greater homology with ERK2, Kss1 or Hog1? Support your answer by citing experimental data.6. Why did the authors test the ability of peptides to inhibit PKA?7. Why did the authors use a Ste7 deletion strain to examine the function of docking defective mutants?8. Ste7 docking mutants had substantial inhibition of binding Fus3 in vitro. Why then was there only a minor effect of Ste7 docking mutants in vivo? How did the authors address this curious result experimentally?9. What is the difference between scaffolding and docking functions? Support your answer with by specifically citing experimental data.10. Provide a biological explanation for the synergistic effect of combining Ste5D746D and Ste72-19 deletion mutants.11. Provide a biological explanation for the reduced β-gal activity in the absence of Ste5 reported in figure 6D.12. Referring to figure 7, construct a similar diagram indicating the interactions between Ste5, Ste11, Ste7, and Fus3 (this may be hand drawn).13. Evaluate the authors’ conclusion that the MAPK-docking site is both necessary and sufficient for the formation of stable MEK-MAPK complexes. Do the in vitro and in vivo data both support the authors’ conclusion?14. How might the existence of modular MAPK-docking sites on multiple proteins contribute to signal-response specificity?15. The authors report differences in the calculated Kd for the Ste7-Fus3 interaction by two difference assays, immunoprecipitation and cosedimentation. Provide an explanation for this discrepancy.16. This work was supported by a Special Fellow Award from the Leukemia and Lymphoma Society to the senior author Lee Bardwell. Why would a organization interested in developing cancer therapeutics fund research on yeast and this work specifically?Part C: The authors use 135 mM salt in the buffer used for the GST-binding assays (Cook, et al, 1996). Why did the authors use this concentration of salt?

 

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Technology Application in Nursing

Due Date: Aug 16, 2017 23:59:59 Max Points: 110

Details:

Each student will select one technology application and describe its use within nursing in general or in patient education. Address the significance of the selected technology, attributes of the selected technology (i.e., accuracy, cost, accessibility, etc.), and provide specific examples with rationale of situations in which the technology application as an educational tool would provide advantages as well as disadvantages. In addition, relate the use of the selected technology application to the appropriate professional standards and competencies.

This assignment may be completed in one of the following formats (with quantitative criteria) listed below:

  1. APA-formatted paper (1,000-1,250 words)
  2. PowerPoint presentation with comprehensive speakers’ notes (12-15 slides)
  3. Podcast (10-15 minutes)
  4. Blog or Web page (1,000-1,250 words)
  5. Any other technology application as approved by the instructor

In addition to the course materials, you are required to use a minimum of three current scholarly, peer-reviewed resources (less than 5 years old).

After you have completed this assignment, you will further post the assignment to the Topic 4 Discussion Forum as specified by the instructor. Within the Topic 4 forum, select and review four technology applications that are new to you in that you have not experienced them in the nursing environment. Explain how each of the four reviewed applications may be modified or adapted for your specific field or to a specific patient population. Ask questions as needed to each classmate about the application. In addition to providing constructive feedback to your peers, your posts should include responses to any questions asked, as well as replies.

APA format is required for essays only. Solid academic writing is always expected. For all assignment delivery options, documentation of sources should be presented using APA formatting guidelines, which can be found in the APA Style Guide, located in the Student Success Center.

This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.

You are required to submit this assignment to Turnitin. Please refer to the directions in the Student Success Center.

 

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