Cell signaling

  1. Some drugs are made of fairly large polar molecules which cannot easily enter cells. To correct this problem,
    drugs are now being delivered into cells by containing them inside liposomes, in which the drug is surrounded
    by a phospholipid bilayer. Given what you have learned about phospholipids, cell membranes and polar vs
    nonpolar molecules, explain how the drug packaged in liposome enters the cell. (Note: I’m not looking for an
    answer you looked up. I’m more concerned with your logic.)
  2. Mackerel are cold-water fish that thrive at 12 °C but can survive at 4 °C. Assuming membrane fluidity
    remains the same, how will the composition of a mackerel’s cell plasma membranes change in terms of length
    of fatty acids in the membrane, the degree of unsaturation of fatty acids, and overall cholesterol concentration
    when the water’s temperature drops from 12 °C to 4 °C
    1.
  3. For the following biological phenomena, identify the signal and the response. There is no need to do
    research on each topic, I am looking for you to read the phenomena and answer using the information given.
    Example: Follicle-stimulating hormone stimulates a cell to secrete growth factors.
    Signal: Follicle-stimulating hormone
    Response: growth factor secretion
    Insulin levels in the blood lead to glucose being imported into fat cells.
    Signal:
    Response:
    A growth factor stimulates the synthesis of proteins needed for a cell to grow
    Signal:
    Response:
    An undifferentiated cell becomes a glial cell after coming in contact with a neuron expressing the Delta protein.
    Signal:
    Response:
  4. Your book divides cell signaling into 4 stages: Receptor activation, signal transduction, response, and
    termination (see Figure 9.3).
    Place each of the following events into the correct stage of cell signaling
    2.
    a. A G protein catalyzes the hydrolysis of GTP to GDP and Pi
    b. Receptor kinase dimerizes after binding insulin
    c. Inactivation of a receptor kinase by a protein phosphatase
    d. Changes in gene expression
    e. Adrenaline binds the extracellular domain of a G protein-coupled receptor
    f. Activation of protein kinase A (PKA)

Sample Solution

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12 Angry Men Leadership and Power

Twelve Angry Men (Links to an external site.)

If you encounter problems while viewing the video, refer to the Textbook, Technology, and Resources page of this course.

Reflecting on the twelve jurors, answer the following:

  1. Legitimate power resided in the Chairman. However, there are two sources of personal power, expertise and referent. Did any jurors possess expert power?
  2. Who among the jurors possessed referent power?

Below are summary descriptions of the twelve jurors.

The Twelve Jurors:

Juror #1 (Foreman): A high-school assistant head coach, doggedly concerned to keep the proceedings formal and maintain authority; easily frustrated and sensitive when someone objects to his control; inadequate for the job as foreman, not a natural leader and over-shadowed by Juror # 8’s natural leadership.

Juror #2: A wimpy, balding bank clerk/teller, easily persuaded, meek, hesitant, goes along with the majority, eagerly offers cough drops to other men during tense times of argument; better memory than # 4 about film title.

Juror #3: ) Runs a messenger service (the “Beck and Call” Company), a bullying, rude and husky man, extremely opinionated and biased, completely intolerant, forceful and loud-mouthed, temperamental and vengeful; estrangement from his own teenage son causes him to be hateful and hostile toward all young people (and the defendant); arrogant, quick-angered, quick-to-convict, and defiant until the very end.

Juror #4: Well-educated, smug and conceited, well-dressed stockbroker, presumably wealthy; studious, methodical, possesses an incredible recall and grasp of the facts of the case; dispassionate, cool-headed and rational, yet stuffy and prim; often displays a stern glare; treats the case like a puzzle to be deductively solved rather than as a case that may send the defendant to death; claims that he never sweats.

Juror #5: Naive, insecure, frightened, reserved; grew up in a poor Jewish urban neighborhood and the case resurrected in his mind that slum-dwelling upbringing; a guilty vote would distance him from his past; nicknamed “Baltimore” by Juror # 7 because of his support of the Orioles.

Juror #6: A typical “working man,” dull-witted, experiences difficulty in making up his own mind, a follower; probably a manual laborer or painter; respectful of older juror and willing to back up his words with fists.

Juror #7: Clownish, impatient salesman (of marmalade the previous year), a flashy dresser, gum-chewing, obsessed baseball fan who wants to leave as soon as possible to attend evening game; throws wadded up paper balls at the fan; uses baseball metaphors and references throughout all his statements (he tells the foreman to “stay in there and pitch”); lacks complete human concern for the defendant and for the immigrant juror; extroverted; keeps up amusing banter and even impersonates James Cagney at one point; votes with the majority.

Juror #8: An architect, instigates a thoughtful reconsideration of the case against the accused; symbolically clad in white; a liberal-minded, patient truth-and-justice seeker who uses soft-spoken, calm logical reasoning; balanced, decent, courageous, well-spoken and concerned; considered a do-gooder (who is just wasting others’ time) by some of the prejudiced jurors; named Davis.

Juror #9: Eldest man in group, white-haired, thin, retiring and resigned to death but has a resurgence of life during deliberations; soft-spoken but perceptive, fair-minded; named McCardle.

Juror #10: A garage owner, who simmers with anger, bitterness, racist bigotry; nasty, repellent, intolerant, reactionary and accusative; segregates the world into ‘us’ and ‘them’; needs the support of others to reinforce his manic rants.

Juror #11: A watchmaker, speaks with a heavy accent, of German-European descent, a recent refugee and immigrant; expresses reverence and respect for American democracy, its system of justice, and the infallibility of the Law.

Juror #12: Well-dressed, smooth-talking business ad man with thick black glasses; doodles cereal box slogan and packaging ideas for “Rice Pops”; superficial, easily-swayed, and easy-going; vacillating, lacks deep convictions or belief system; uses advertising talk at one point: “run this idea up the flagpole and see if anybody salutes it.”

Sample Solution

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Annual Report Analysis and Executive Memo and Video Presentation

A critical financial accounting skill is the ability to read, analyze, and make actionable decisions from any financial statement. Business leaders gain valuable information from the annual reports of direct competitors, companies that operate in similar fields, and companies in which they are considering an investment or partnership.

Instructions

You are the CFO of a family owned, regional carpet/flooring retailer looking to partner with a manufacturer and focus on selling their products exclusively. Your CEO has narrowed the field down to two manufacturers, and is requesting your analysis and guidance. She has asked you to do a financial review of recent results from Mohawk Industries (MHK) and The Dixie Group (DXYN). You have decided to organize your work into TWO components:

Part A: Financial Analysis Snapshot of key data from the annual reports

Part B: Executive Memo and brief Video Presentation of your analysis

Sample Solution

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Epic and Cerner as the two leading vendors

Review the Epic.com and Cerner.com websites and research articles about the firms
Study the RFP template and compare Epic and Cerner on key criteria to base a decision on the best EHR Software system to purchase for St. Rose Hospital
Assume that you are a consultant hired to make a recommendation to the CEO, CFO and CIO Chief Information Officer

Sample Solution

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