With regards to the induction of cutaneous pruritus list five (5) endogenous pruritogens (mediators of pruritus) and their receptors.

2. Answer all parts of this question:
a) With regards to the induction of cutaneous pruritus list five (5) endogenous
pruritogens (mediators of pruritus) and their receptors. (A table is acceptable.)
(5 marks)
b) Describe the peripheral (4 marks), spinal (4 marks) and central (2 marks) neural
pathways associated with itch perception of a cutaneous induced pruritus.
(Diagrams are acceptable.) (total 10 marks)
3. For each of the following components of the innate immune system, describe briefly
how they would help to provide protection against cutaneous staphylococcal
infection. Your answer should include the molecular mechanisms that provide the
protective or antimicrobial effect. Each component listed is of equal value.
(total 15 marks)
i. antimicrobial peptides
ii. toll-like receptors
iii. keratinocyte derived interleukin-1
iv. complement
v. iron binding proteins
vi. mast cells
vii. neutrophil extracellular traps
Section B continued over page
Veterinary Dermatology Paper 1 Page 7 of 9
4. Answer all parts of this question:
a) Briefly describe how B cells and T cells are differentiated based on cell surface
markers. (2 marks)
b) Name the different types of T lymphocytes. For each subtype name the cell
surface markers, cytokine production profile and its major function. (13 marks)

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