Which of the metabolic pathways that we have studied would be affected by a thiamine deficiency? List the affected enzymes

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9.) (4 pts) A thiamine deficiency causes the disease beriberi. The symptoms are pain in the limbs, weakness of the muscles an
9.) (4 pts) A thiamine deficiency causes the disease beriberi. The symptoms are pain in the limbs, weakness of the muscles and distorted skin sensations. The heart becomes enlarged and the cardiac output diminishes. (a) Which of the metabolic pathways that we have studied would be affected by a thiamine deficiency? List the affected enzymes. Pyruvate dehydrogenasc (b) A deficiency of thiamine elevates the blood levels of pyruvate and a-ketoglutarate. How are these effects related to the deficiency? boldog

 

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