Opioid Use & Hypogonadism

Opioid abuse is a major health concern that has surged over the decade of the 2010s, affecting both rural

and urban populations. Other health concerns, such as the spread of HIV and other infectious diseases,

has followed. A lesser-known complication of opioid use and abuse, however, is opioid-induced

hypogonadism due to endocrine axis disruption. There were only a handful of case reports in the 2000s,

with this number increasing greatly by the early 2010s.
In your response, describe the endocrine axis that is most affected by opioid use and explain how it

affects both sexual development and function over the lifespan. Which hormone(s) and pathways are the

most affected, and why? What other associated commodities have followed?

Sample Solution

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