TOTAL PLASMA VOLUME IS IMPORTANT IN DETERMINING THE REQUIRED PLASMA COMPONENT IN BLOOD REPLACEMENT

Total plasma volume is important in determining the required plasma component in blood replacement therapy for a person undergoing surgery. Plasma volume is influenced by the overall health and physical activity of an individual. Suppose that a random sample of 46 male firefighters are tested and that they have a plasma volume sample mean of x = 37.5 ml/kg (milliliters plasma per kilogram body weight). Assume that = 7.00 ml/kg for the distribution of blood plasma.
(a) Find a 80% confidence interval for the population mean blood plasma volume in male firefighters. What is the margin of error? (Use 2 decimal places.)
lower limit=
upper limit=
moe =

(b) What conditions are necessary for your calculations? (Select all that apply.)
the distribution of weights is normal
is known
n is large
is unknown
the distribution of weights is uniform

(c) Give a brief interpretation of your results in the context of this problem.
The probability that this interval contains the true average blood plasma volume in male firefighters is 0.80.
20% of the intervals created using this method will contain the true average blood plasma volume in male firefighters.
The probability that this interval contains the true average blood plasma volume in male firefighters is 0.20.
80% of the intervals created using this method will contain the true average blood plasma volume in male firefighters.

(d) Find the sample size necessary for a 80% confidence level with maximal/marginal error of estimate E = 2.00 for the mean plasma volume in male firefighters.

DNA

Document Preview: 

DNA 1
DNA vaccination is a promising new approach for the prevention and treatment of many diseases because of its ability to induce both humoral and cellular immune responses against antigens encoded by recombinant DNA. This strategy has been used successfully for infectious diseases and potentially can be applied for malignant conditions.
Although, DNA vaccines have a number of disadvantages such as Risk of affecting genes controlling cell growth, they also have a several of advantages over conventional vaccines which one of the most important is the ability to induce a wide range of immune response types. In fact, several approaches have been investigated to improve DNA vaccines including plasmid design, delivery techniques, ect. The goals of the various clinical trials were to demonstrate the safety and tolerability of the candidate vaccines, and to explore the efficacy of DNA vaccines in humans.
This presentation focuses on how DNA vaccines work as well as the mechanisms by which DNA vaccination induces immune responses and some representative DNA cancer vaccine studies ( at phases 1&2) .An overview of the human clinical trials is also presented.
www.scancell.co.uk/AssetLibrary/Antibodies designed as effective cancer vaccines.
www.uiowa.edu/ Prostate cancer vaccines-Update on clinical development.
www.biomedcentral/DNA Vaccines: Developing New Strategies against Cancer.
www.bion.Regulation of DNA vaccines and gene therapy on animals.pdf
www.sciencedirect.com
www.nature.com
www.biolife.com

What does just-in-time inventory management have to do with the Carle Heart Center in Urbana, Illinois?

What does just-in-time inventory management have to do with the Carle Heart Center in Urbana, Illinois? The Carle Heart Center is one of the most sophisticated cardiac-care facilities in the Midwest. Integral to the success of Carle are three separate cardiac catheterization labs that are miles apart. These cath labs have pioneered techniques and technologies ranging from intravascular brachytherapy to digital cardiovascular imaging. The latest addition to this forward-thinking heart care center is a department-wide networking system from General Electric Medical Systems called CardioLink. Part of the CardioLink is a just-in-time inventory system. According to Carle’s Cath Lab Manager Alan Kettelkamp, “Department- wide access to our Lab Management Tools not only eliminates the need for maintaining individual inventory systems for each lab, it also allows us to apply just-in-time techniques. We simply push a button to see which supplies are below our par levels, by vendor. Our inventory specialists can then print out replenishment orders and fax them out for next-day shipment. We’re even able to enter the replenishments into our system with a bar-code reader. This system has perfected our order-management process, and it has allowed us to reduce our total inventory significantly.”
1. What are the benefits of the just-in-time inventory management system to Carle’s Cath Lab?
2. What do you think would be a “safe” inventory level for Carle’s Cath Lab? Is it 3 or 4 days as with Dell, or is it longer?
3. In what other critical service areas besides health care would a just- in-time inventory management system prove beneficial?

How closely is the literature reviewed in the study related to the previous literature?

REVIEW OF PREVIOUS RESEARCH

1. How closely is the literature reviewed in the study related to the previous literature?
2. Is the review recent? Are there any outstanding references you know about that were left out?

PROBLEM AND THE PURPOSE

3. Can you understand the statement of the problem?
4. Is the purpose of the study clearly stated?
5. Does the pupose seem to be tied to the literature that is reviewed?
6. Is the objective of the study clearly stated?
7. Is there a conceptual rationale to which the hypotheses are grounded?
8. Is there a rational for why the study is an important one to do?

HYPOTHESES

9. Are the research hypotheses clearly stated?
10. Are the research hypotheses explicitly stated?
11. Do the hoypotheses state a clear association between variables?
12. Are the hypotheses grounded in theory or in a review and presentation of relevant literature?
13. Are the hypotheses testable?

METHOD

14. Are the independent and dependent variables clearly defined?
15. Are the definition and description of the variables complete?
16. Is it clear how the study was conducted?

SAMPLE

17. Was the sample selected in such a way that you think it is representative of the population?
18. Is it clear where the sample came from and how it was selected?
19. How similar are the subjects in the study to those that have been used in other similar studies?

RESULTS AND DISCUSSION

20. Does the author relate the results to the review of the literature?
21. Are the results related to the hypotheses?
22. Is the discussion of the results consistent with the results?
23. Does the discussion provide closure to the initial hypotheses presented by the author?

REFERENCES

24. Is the list of references current?
25. Are the refences consistent in their format?
26. Are the references complete?
27. Does the list of references reflect some of the most important reference sources in the field?