NURSING: Advanced Pathophysiology

 Adaptive Response

As an advanced practice nurse, you will examine patients presenting with a variety of disorders. You must, therefore, understand how the body normally functions so that you can identify when it is reacting to changes. Often, when changes occur in body systems, the body reacts with compensatory mechanisms. These compensatory mechanisms, such as adaptive responses, might be signs and symptoms of alterations or underlying disorders. In the clinical setting, you use these responses, along with other patient factors, to lead you to a diagnosis.

Consider the following scenarios:

Scenario 1:

Jennifer is a 2-year-old female who presents with her mother. Mom is concerned because Jennifer has been “running a temperature” for the last 3 days. Mom says that Jennifer is usually healthy and has no significant medical history. She was in her usual state of good health until 3 days ago when she started to get fussy, would not eat her breakfast, and would not sit still for her favorite television cartoon. Since then she has had a fever off and on, anywhere between 101oF and today’s high of 103.2oF. Mom has been giving her ibuprofen, but when the fever went up to 103.2oF today, she felt that she should come in for evaluation. A physical examination reveals a height and weight appropriate 2-year-old female who appears acutely unwell.  Her skin is hot and dry. The tympanic membranes are slightly reddened on the periphery, but otherwise normal in appearance. The throat is erythematous with 4+ tonsils and diffuse exudates. Anterior cervical nodes are readily palpable and clearly tender to touch on the left side. The child indicates that her throat hurts “a lot” and it is painful to swallow. Vital signs reveal a temperature of 102.8oF, a pulse of 128 beats per minute, and a respiratory rate of 24 beats per minute.

Scenario 2:

Jack is a 27-year-old male who presents with redness and irritation of his hands. He reports that he has never had a problem like this before, but about 2 weeks ago he noticed that both his hands seemed to be really red and flaky. He denies any discomfort, stating that sometimes they feel “a little bit hot,” but otherwise they feel fine. He does not understand why they are so red. His wife told him that he might have an allergy and he should get some steroid cream. Jack has no known allergies and no significant medical history except for recurrent ear infections as a child. He denies any traumatic injury or known exposure to irritants. He is a maintenance engineer in a newspaper building and admits that he often works with abrasive solvents and chemicals. Normally he wears protective gloves, but lately they seem to be in short supply so sometimes he does not use them. He has exposed his hands to some of these cleaning fluids, but says that it never hurt and he always washed his hands when he was finished.

Scenario 3:

Martha is a 65-year-old woman who recently retired from her job as an administrative assistant at a local hospital. Her medical history is significant for hypertension, which has been controlled for years with hydrochlorothiazide. She reports that lately she is having a lot of trouble sleeping, she occasionally feels like she has a “racing heartbeat,” and she is losing her appetite. She emphasizes that she is not hungry like she used to be. The only significant change that has occurred lately in her life is that her 87-year-old mother moved into her home a few years ago. Mom had always been healthy, but she fell down a flight of stairs and broke her hip. Her recovery was a difficult one, as she has lost a lot of mobility and independence and needs to rely on her daughter for assistance with activities of daily living. Martha says it is not the retirement she dreamed about, but she is an only child and is happy to care for her mother. Mom wakes up early in the morning, likes to bathe every day, and has always eaten 5 small meals daily. Martha has to put a lot of time into caring for her mother, so it is almost a “blessing” that Martha is sleeping and eating less. She is worried about her own health though and wants to know why, at her age, she suddenly needs less sleep.

To Prepare

· Review the three scenarios, as well as Chapter 6 in the Huether and McCance text.

· Identify the pathophysiology of the disorders presented in each of the three scenarios, including their associated alterations. Consider the adaptive responses to the alterations.

· Review the examples of “Mind Maps—Dementia, Endocarditis, and Gastro-oesophageal Reflux Disease (GERD)” media in this week’s Learning Resources. Then select one of the disorders you identified from the scenarios. Use the examples in the media as a guide to construct a mind map for the disorder you selected. Consider the epidemiology, pathophysiology, risk factors, clinical presentation, and diagnosis of the disorder, as well as any adaptive responses to alterations.

· Review the Application Assignment Rubric found under Course Information

To Complete

Write a 2- to 3-page paper excluding the title page, reference page and Mind Map that addresses the following:

· For each of the three scenarios explain the pathophysiology, associated alterations and the patients’ adaptive responses to the alterations caused by the disease processes.  You are required to discuss all three scenarios within the paper component of this assignment.

· Construct one mind map on a selected disorder presented in one of the scenarios. Your Mind Map must include the epidemiology, pathophysiology, risk factors, clinical presentation, and diagnosis of the disorder, as well as any adaptive responses to alterations.

                                                        Learning Resources

Required Readings

Huether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis, MO: Mosby.

  • Chapter 6, “Innate Immunity:      Inflammation and Wound Healing”

This chapter examines how the body responds to injury and infection by exploring the first, second, and third lines of defense. It also covers wound healing and alterations of the wound healing process.

  • Chapter 7, “Adaptive      Immunity”

This chapter examines the third line of defense, adaptive immunity. It also covers the roles of antigens and immunogens, the humoral immune response, cell-mediated immunity, and the production of B and T lymphocytes in the immune response.

  • Chapter 8, “Infection and      Defects in Mechanism of Defense”

This chapter covers the epidemiology, clinical presentation, and treatment of disorders resulting from infection, deficiencies in immunity, and hypersensitivity. It also examines the pathophysiology of an important immune disorder—HIV/AIDS.

  • Chapter 9, “Stress and      Disease”

This chapter evaluates the impact of stress on various body systems and the immune system. It also examines coping mechanisms and disorders related to stress.

  • Chapter 10, “Biology of      Cancer”

This chapter explores the developmental process of cancer and factors that impact the onset of cancer at the cellular level. It also describes various treatment options.

  • Chapter 11, “Cancer      Epidemiology”

This chapter reviews genetic, environmental, behavioral, and diet-related risk factors for cancer. It also examines types of cancers that result from risk factors.

  • Chapter 12, “Cancer in      Children and Adolescents”

This chapter focuses on the presentation and prognosis of childhood cancers. It examines the impact of genetic and environmental factors on these cancers.

  • Chapter 38, “Structure and      Function of the Musculoskeletal System”

This chapter covers the structure and function of bones, joints, and skeletal muscle. It also explores effects of aging on the musculoskeletal system.

  • Chapter 39, “Alterations of      Musculoskeletal Function”

This chapter examines the pathophysiology, clinical manifestations, and evaluation and treatment of bone, joints, and skeletal muscle disorders. Additionally, it explores musculoskeletal tumors, osteoarthritis, and rheumatoid arthritis.

  • Chapter 40, “Alterations of      Musculoskeletal Function in Children”

This chapter includes musculoskeletal disorders that affect children, such as congenital defects, bone infection, juvenile idiopathic arthritis, muscular dystrophy, musculoskeletal tumors, and nonaccidental trauma.

  • Chapter 41, “Structure,      Function, and Disorders of the Integument”

This chapter begins with an overview of the structure and function of skin. It then covers effects of aging on skin, as well as disorders of the skin, hair, and nails.

  • Chapter 42, “Alterations of      Integument in Children”

This chapter covers alterations of the integument that affect children. These include acne vulgaris, dermatitis, infections of the skin, insect bites and parasites, vascular disorders, and other skin disorders.

Hammer, G. G. , & McPhee, S. (2014). Pathophysiology of disease: An introduction to clinical medicine. (7th ed.) New York, NY: McGraw-Hill Education.

  • Chapter 3, “Disorders of the      Immune System”

This chapter explores the anatomy and physiology of the immune system. It also explores the pathophysiology of various immune disorders such as primary immunodeficiency diseases and AIDS.

  • Chapter 8, “Diseases of the      Skin”

This chapter begins with an overview of the anatomy and physiology of skin. It also explores the pathophysiology of various types of skin lesions and inflammatory skin diseases.

  • Chapter 24, “Inflammatory      Rheumatic Disease”

This chapter explores the pathogenesis of inflammation and its role in rheumatic diseases. It also examines the clinical presentation, etiology, pathophysiology, and clinical manifestations of rheumatic diseases such as gout and rheumatoid arthritis.

Required Media

Zimbron, J.  (2008). Mind maps—Dementia, endocarditis, and gastro-oesophageal reflux disease (GERD) [PDF]. Retrieved from http://www.medmaps.co.uk/beta/

Gastro-oesophageal reflux disease. [Image]. Used with permission of MedMaps.

This media provides examples of mind maps for dementia, endocarditis, and gastro-oesophageal reflux disease (GERD).

Optional Resources

Arthritis Foundation. (2012). Retrieved from http://www.arthritis.org/ 

Lupus Foundation of America. (2012). Retrieved from http://www.lupus.org/newsite/index.html 

Case Study: Epidemiological Measures Of MMR Vaccine

DUE 12/27  10 P.M EST

MATERIAL ATTACHED AND YOU’RE ONLY COMPLETING SECTION (B,C AND D) Total of 8 questions

 

Understanding health risks and interpreting them correctly is an important function for anyone involved in public health. Often, the results of epidemiological studies are reported in the media as “known facts,” when indeed that is not the case. Such is the situation for the reported association between vaccinations and the risk of autism.

For this Case Study Assignment, you will analyze and interpret the epidemiological evidence for a possible association between vaccination with the measles/mumps/rubella (MMR) vaccine and the occurrence of autism

 

Using the information provided in the case study, complete Sections B, C, and D (pp. 5–10), typing your answers into a separate document.

Be sure that your completed document contains your responses to all questions from Sections B, C, and D of the case study.

Kristina Simeonsson, MD, MSPH

Jeffrey Bethel, PhD Suzanne Lea, PhD, MPH

 

 

 

Department of Public Health Brody School of Medicine

East Carolina University Greenville, NC 27834

STUDENT VERSION

 

 

Weighing the Evidence: Misconceptions about

measles-mumps-rubella (MMR) vaccine and autism

 

 

 

2

Abstract: Understanding study design is the foundation for accurately interpreting research. Health care professionals should be able to distinguish well-conducted research from poorly conducted research and know how to apply that knowledge to the care of their community. After participating in this exercise students will be able to recognize the advantages and disadvantages of experimental versus observational studies. This case discusses the proposed association between the MMR vaccine and autism. Students will be prompted to create a study that investigates this claim and to utilize the fundamentals of epidemiology to measure the strength of association between these two variables. Recommended Reading:

 Madsen KM et al. A population-based study of measles-mumps-rubella vaccination and autism. N Engl J Med 2002;347(19)1477-82.

 Offit, PA. & Coffin, SE. Communicating science to the public: MMR vaccine and autism: Vaccine 2003: 22(1) 1-6.

 Smeeth L et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet 2004;364:963-9.

Objectives: At the end of this session, students will be able to:

 Recognize criteria for initiating experimental and observational studies  Identify key design components of studies  Describe the advantages and disadvantages of various study designs  Calculate and interpret outcome measures in cohort and case-control studies  Interpret data from observational studies looking at MMR vaccination and autism

 

 

 

 

 

3

Introduction

1. What have you heard about an association between vaccines and autism?

What are some of the hypotheses you have heard about or read about?

2. What types of studies would you recommend to look at an association between vaccines and autism?

 

 

 

 

 

4

Section A: Study Design Design a study to look at the association between MMR vaccine and autism.

1. Cohort study a. How will you assemble your cohort ?

 

b. What are your inclusion/exclusion criteria for participation in the study?

c. Exposure status: How will you define and measure vaccination status?

d. Outcome status: How will you define and measure autism?

e. What measure of association will you calculate in a cohort study?

2. Case-control study

a. What is your definition of a case? b. How will you identify cases?

 

c. What is your definition of a control?

d. How will you identify controls?

e. Exposure status: How will you define and measure vaccination status?

f. What measure of association will you calculate in a case-control study?

 

 

 

5

Section B: Calculating Measures of Association Over 25 studies have been conducted which have failed to show an association between MMR vaccine and autism. Below are some data from two of these studies (one cohort and one case-control). Calculate the measure of association for each study after completing the 2×2 table and interpret the measure of association.

1. Cohort study by Madsen et al (NEJM 2002) Of the 537,303 children in the cohort, 440,655 (82.0 percent) had received the MMR vaccine. We identified 316 children with a diagnosis of autistic disorder; 263 of the cases had been vaccinated with MMR (83%); 53 children with autism had not been vaccinated.

 

 

 

 

2. Case control study by Smeeth et al (Lancet 2004) 1294 cases of pervasive developmental disorder (PDD) and 4469 controls were included. 1010 cases (78·1%) had MMR vaccination recorded before diagnosis, compared with 3671 controls (82·1%) before the age at which their matched case was diagnosed.

 

 

 

 

 

 

 

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Section C: Interpreting results Review the following data from the aforementioned studies and answer the following questions. FIGURE 1: Table 1 from Madsen et al., 2002

 

 

 

7

 

1. Describe the characteristics in Table 1 in terms of what type of data they are (discrete / qualitative versus continuous / quantitative).

 

Using the chi-square test (see footnote of FIGURE 1), authors found significant differences in certain characteristics of vaccinated and unvaccinated children.

 

2. What characteristics showed no differences between the two groups? What characteristics showed differences between the vaccinated and unvaccinated groups?

 

3. What do these differences mean?

 

 

 

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FIGURE 2: Table 2 from Madsen et al., 2002

 

4. Do the data in Figure 2 above show an association between MMR vaccine and risk of autism?

 

 

 

 

9

 

5. Do the data in Figure 3 from Smeeth et al show an association between MMR vaccine and risk of autism?

FIGURE 3: Tables 1 and 2 from Smeeth et al 2004 Table 1: Association between Pervasive Developmental Disorder (PDD) and MMR vaccination before index date, before and after third birthday, and before and after age 18 months.

UK General Practice Research Database (GPRD) Table 2: Association between diagnosis of autism or other PDD and MMR vaccination

UK General Practice Research Database (GPRD)

 

 

 

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Section D: Conclusion Since 1998, numerous well-designed studies have found no link between vaccines and autism (see table below). Why do you think some parents are still fearful of vaccines? What is your role as future healthcare providers in counseling patients about vaccines?

Offitt PA, Coffin SE; Vaccine 2003

Epidemiology of Health and Illness.

Epidemiology of Health and Illness.

Transforming the Public’s Health Care Systems.

Global Health

Please read chapter 4, 5 & 7 of the class textbook and review the attached Power Point presentations.  Once done answer the following questions;

1. How does the epidemiologic triad apply to health issues we see in the hospital? What are some common diagnoses in the acute care setting? What about in the community setting? How does the epidemiologic triad differ when a nurse is providing care to someone in the community or in his home? Does the nurse have more or less control in either arena?

2. Discuss the data presented regarding obesity in America in the Ethical Connection feature on page 118.  Please review the data and discuss your feelings about the role of community health nurses in community nutrition.

3. What are some of the causes for increases in healthcare costs in recent years, as outlined in the chapter?  Brainstorm some examples that you have actually witnessed in the clinical setting. Can any of these factors be modified? What could nurses do to help cut down on costs related to the different factors?

4. Why are the causes of morbidity and mortality in other countries different than in the United States? In what ways are they the same? Why do those differences exist? What types of services & interventions are needed in less developed countries to help with their health issues?

As stated in the class syllabus please present your assignment in an APA format word document, Arial 12 font attach to the thread in the discussion board title “Week 2 discussion questions”.  A minimum of 2 references no more than 5 years old are required with 2 replies to any of your peers sustained with the proper references.  A minimum of 500 words without counting the first and reference page are required.

Text and materials:

Saucier Lundy, K & Janes, S.. (2016). Community Health Nursing. Caring for the Public’s Health. (3rd ed.) ISBN: 978-1-4496-9149-3

Publication Manual American Psychological Association (APA) (6th ed.).

2009 ISBN: 978-1-4338-0561-5

The Influence Of Consequential Ethics As An Ethical Framework

 The influence of consequential ethics as an ethical framework (the greatest good for the greatest number) opposes the ethical principle of deontology (i.e., the rightness of an act itself determines what is right). Both of these impact the nursing profession. Modern social exchange theories are based on the principle of utility. Read the assumptions of social exchange theory and consider how these would affect the nurse-patient relationship, compared to how these impact the nurse within the health care environment. To what extent are all theories ethical? Is social exchange theory compatible with the values of the nursing profession?