Discuss diacylglycerol in nephron.

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Write a 1 page paper on diacylglycerol in nephron. Cell Signaling Pathway: Three pathways of phosphatidylcholine metabolism lead to DAG generation, catalyzed by PC specific phospholipase, PC-specific phospholipase D and phosphatidic acid phosphatase (PAP) activation, and conversion of ceramide into sphingomyelin (SM) catalyzed by PC ceramide choline phosphotransferase respectively (Carbon & Lopez-Sanchez, 917).

Changes in Cell Signaling Pathway with Age: With age, the diminishing DAG levels enable its action as an attenuator of the PKC system (Nogaroli et al, 80).

Pathophysiology Due to a Problem with the Signaling Pathway: Activation of the DAG-protein kinase C (PKC) pathway is a recognized characteristic of diabetes. “PKC is an important intracellular pathway that can be activated by many of the metabolic and hemodynamic factors involved in the pathogenesis of diabetic nephropathy” (Schrijvers, Vriese & Flyvbjerg, 971).&nbsp.

Conclusion: From the above study it can be concluded that DAG has a significant role in nephrons and need to be studied in details to understand its functioning.

Read the Performance Appraisal at Telespazio: Aligning Strategic Goals to People

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Read the Performance Appraisal at Telespazio: Aligning Strategic Goals to People Development case study located in Topic resources. Discuss the assessment of employees within the Telespazio organization. In 1,000-1,250 words, explain how the organization uses the appraisal assessments to identify employee roles, the current appraisal systems, performance ratings, and Telespazio’s practices for performing appraisal interviews. Decide what changes or strategies could be implemented to current performance appraisal practices. Consider a new performance appraisal tool that would benefit this highly matrixed, global company and an effective method for conducting a performance appraisal interview. Describe the benefits of using both the proposed appraisal tool and appraisal interview during the performance evaluation process. Suggest a minimum of two recommendations to Telespazio leadership which would meet the performance appraisal expectations of fair and realistic criterion, and professional development and motivation of the employees. Prepare this assignment according to the guidelines found in the APA Style Guide, located in the Student Success Center. This assignment uses a rubric. Review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion. You are required to submit this assignment to LopesWrite. A link to the LopesWrite technical support articles is located in Class Resources if you need assistance.

Analysis of Sony Corporations Blu-Ray Technology.

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I need help creating a thesis and an outline on Analysis of Sony Corporations Blu-Ray Technology. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. The purpose of this research paper is to analyze Sony’s Blu-Ray technology and determine its viability to become a profitable product in the marketplace.

The proposed research study would utilize various methods to analyze Sony Corporation with an emphasis on its Blu-Ray technology. The research is based on the use of secondary data as the primary source of information. Secondary data is a research technique which tests theories and hypothesis based on data that is readily available in the public realm (Disc, 2003). This proposal would utilize sources such as the Sony’ corporate website, other information available on the worldwide web, journal articles and information obtained from professional databases such as EBSCOhost, ProQuest and Plunkett Research databases. Different analytic techniques will be utilized to study the company and its Blu-Ray technology. Some the techniques include analyzing the marketplace, identifying the key competitors, describing the advantages and disadvantages of the technology, studying the internal and external environments, performing a SWOT analysis and identifying the key issues Sony faces in the introductory phase of its Blu-Ray technology.

This initial proposal for a research study of Sony’s Blu-Ray technology limits itself to identifying the problems the company is facing with its Blue-Ray technology and the different issues and complication that have surged with the introduction of the products. Other business aspects such as Sony’s strategy and its main competitors are also described in the research proposal. In order to understand the situation, the first thing is to understand what Blu-Ray technology is. Blu-Ray technology (DB) is the next-generation optical disc format to enable recording, rewriting and playback of high definition video, as well as storage of large amounts of data (Blu-ray, 2007). The technology uses a blue-violet laser instead of the red laser technology which allows greater precision in the reading and information to be stored in a small space inside the disc.

Discussion on Je Suis Charlie.

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I need help creating a thesis and an outline on Je Suis Charlie. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. Twitter is the first media channel to use this slogan, and it was under the hashtag, #jusuischarlie. This slogan was also trending in another hashtag, #iamcharlie, which is a translation of Je Suis Charlie (Lee, 2015). Within a span of two weeks after the attack, the slogan was very popular on Twitter and the history of Twitter.

This concept of Je Suis Charlie became acceptable worldwide, and it was displayed in animated cartoons, and this includes the famous cartoon, the Simpsons (Lee, 2015). The print media, such as the New York Times, The Guardian, also embraced this term, and they constantly used it, while reporting on the terrorist attack, at the Charlie Hebdo satirical News Paper. The reason for this attack is the depiction of a cartoon image of the prophet Muhammad (Lee, 2015).

This paper tracks the development of this story, across the media channels, and this includes both the mainstream and the alternative media. The mainstream media organizations that this paper tracks this story from, includes, BBC, CNN and Yahoo. The alternative media, that this paper analyzes the manner which they reported this story, is WSWS, which is an abbreviation of the World Socialist Web, and the news channel, referred to as Democracy Now.

Yahoo Media is one of the mainstream media organizations that were responsible for covering this news event. In its coverage of this event, the headline of the news story begins, with the words, “Paris shooting…. ”(Yahoo News, 2015). This title introduces the audience to what had just happened. It tries to create suspense to the reader, and this is in a bid of making the reader read more from the topic. Creation of suspense is one of the most important elements of a news story, and this is because it would catch the eyes of a reader, creating a desire to the person, to go on and read the paper (Lee, 2015). This suspense is quenched when the title, further goes on to denote that, the suspected terrorists, who were involved in the Charlie Hebdo attacks, were all killed by police officers (Yahoo News, 2015). Yahoo Media does not provide a detailed analysis of what was happening.&nbsp. &nbsp.