Write 5 pages thesis on the topic advanced genetic analysis review. The example of the lin-18 genes, when combined with mom-2, suggests that the probability&nbsp.will be less than 10%. Neither of the genes yields probabilities equal to 10% or even greater than 1%, there is no data that indicates a higher percentage. These mutations are likely to be hypomorphic, as they lower the probability of expression.

It is probable that during embryonic development, there are two separate stages in which&nbsp.lin-44 and mom-2 are activated leading to a protein that completes a quaternary structure involving the lin-17 and lin-18 membrane proteins. The lack of 44 and mom leads to a protein conformation error resulting in the bi-vulva condition. The available data implies a developmental process in which lin-17 and 18 are transcribed into proteins localized to the membranes, but their natural conformation depends upon the secretory gene-products of lin-44 and mom 2.

One possible test for this idea would likely be a form of X-ray crystallography to elucidate the structure produced by expression of lin-17 and lin-18, and then to match the structures with the products of 44 and mom. This theory would predict the combination of all these gene products resulting in a single quaternary structure. If no stable structure can be elucidated, or if the secretory products themselves formed a quaternary structure, this would contradict the model.

Reporter gene mom-2 has a signaling function that effects lin-18, but mom-1 does not, as it does not affect the VPC-4 cell. It is possible that mom-2&nbsp.assumes control of the maturation process begun in larval stage one by lin-18,&nbsp. and its function is distinct from mom-1.