11-Discussion: Off-Label Drug Use in Pediatrics
The unapproved use of approved drugs, also called off-label use, with children is quite common. This is because pediatric dosage guidelines are typically unavailable since very few drugs have been specifically researched and tested with children.
When treating children, prescribers often adjust dosages approved for adults to accommodate a child’s weight. However, children are not just “smaller” adults. Adults and children process and respond to drugs differently in their absorption, distribution, metabolism, and excretion. Children even respond differently during stages from infancy to adolescence. This poses potential safety concerns when prescribing drugs to pediatric patients. As an advanced practice nurse, you have to be aware of safety implications of the off-label use of drugs with this patient group.
To prepare:

Review the Bazzano et al. and Mayhew articles in the Learning Resources. Reflect on situations in which children should be prescribed drugs for off-label use.
Think about strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Consider specific off-label drugs that you think require extra care and attention when used in pediatrics.

With these thoughts in mind:
Post an explanation of circumstances under which children should be prescribed drugs for off-label use. Then, describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriptions and names of off-label drugs that require extra care and attention when used in pediatrics.
 
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2 Pg APA style paper on centralization vs decentralization and specialization of roles in virtual team work.

Prompt:

Propose the most effective way (i.e., a set of logical recommendations) to structure a virtual team (with members located within and some external to the United States and possibly some from different national cultures) to meet the goals of 1) team member satisfaction/growth and 2) producing results that achieve the team’s directive from upper level management.

As part of your analysis of how to structure the team to meet those goals, your analysis and recommendations (based on course concepts and your research on why teams succeed or fail) should address each of the following issues (under separate subheadings):

1. Differentiation (i.e., specialization) of roles and functions and Integration (i.e.,
   coordination) of the work
2. Centralization versus Decentralization

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