MSC exosome effects

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Does MSC exosome increased polarization of M2 Macrophages promote functional recovery in rat SCI.

  1. What markers for M1 and M2 macrophages will you use?
  2. How do you identify these on M1 and M2 macrophages in the spinal cord? What reagents and tools will be used?
  3. What tools are used to observe that MSC exosomes are in M2 macrophages? How do you know that they are not in M1s?
  4. Identify one cytokine that is pro-inflammatory and one that is anti-inflammatory, which are secreted by M1 and M2 macrophages, respectively. See the clue below.
  5. How do you do a BBB score? What does it tell you?
  6. How do you measure white matter? What does it represent?

The clue to #4. Look up Laskin https://pubs.acs.org/doi/10.1021/tx900086v read the abstract and figure carefully.

these are large articles, thus you only need to highlight several sections that you plan to use.

Qu & Aang (2017) was carried out to establish how Mesenchymal Stem Cells (MSCs) influence the reparative actions in SCI.
Cheng &He (2017) established that Macrophages play a critical role in reactivating healing for secondary injuries.
Gennsel & Zhang (2015) provides a comparative analysis of the recovery and inflammatory reactions between SCI and tissues that achieves full wound resolution.

Sample Solution

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The Arizona English Language Proficiency Standards (ELPS)

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Using the Arizona English Language Proficiency Standards (ELPS), create a reading learning experience you would implement with ELLs to support fluency and comprehension of the language. Be sure to specify the grade or age group and level of your students.
Include a 500-600 word description of the learning experience, the materials needed, and how it would be carried out. This description should also include the differentiation strategies you would integrate to support the following language proficiency levels:
Pre-emergent
Basic
Intermediate

Sample Solution

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Importance of disaster planning, preparation, and mitigation.

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Discuss the importance of disaster planning, preparation, and mitigation.
Evaluate the hazard assessment process and the role of the firefighter in community disaster planning and recovery.
Briefly describe hazard response and planning procedures.
Define the impact of hazard occurrence on community response.
Define the parameters and effectiveness of an Emergency Operations Plan (EOP) and its components.
Differentiate the multilevel agency responsibilities in disaster mitigation.
Define the relationships between disaster planning, mitigation, and recovery.
Describe how the information in this class will impact your life.

Sample Solution

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Sudoku puzzles

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It is supposed to be about how the topic which is sudoku puzzles are connected to mathematics. The writer should do research on how puzzles especially sudoku puzzles are connected to mathematics from two sources which should be cited. The question is what is the mathematics of sudoku puzzles? Or puzzles in general. It can include maths on how we use maths in puzzles

Sample Solution

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