What is the differences between nicotinic and muscarinic receptor?

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Here’s what I’ve got.

Nicotinic and Muscarinic receptors are both Acetylcholine (ACh) receptors. The same neurotransmitter binds to them, yet their mechanism of action (MOA) differs quite greatly due to their uniqueness.

First off Nicotinic Receptors are ionotropic. Which means that when ACh binds to it, ions flow through it. It acts as a channel for positively charged ions, mainly sodium. Which depolarizes the cell.

You can find N1 Nicotinic receptors at neuromuscular junctions. In which they play an integral part in allowing your muscles to move. N2 Nicotinic receptors are in the brain and also in the Autonomic and Parasympathetic nervous systems.

While on the other hand Muscarinic Receptors have a different MOA. Instead of becoming an ion channel for sodium, they use a G-Protein. When ACh binds to the receptor, this protein changes shape, which then allows it to phosphorylate various second messengers.

There are five different types of Muscarinic Receptors M1, M3 & M5 are excitatory receptors because their G-Protein stimulates Phopholipase C, which then activates IP3 and DAG. The other two, M2 and M4, are inhibitory.

You find Muscarinic Receptors in the brain, heart, smooth muscle, or in the Parasympathetic nervous system. While Nicotinic Receptors are found in the Sympathetic nervous system, Muscarinic receptors are not. This is the crucial difference.

The main difference between the two is their MOA, one uses Ions (Nicotinic) and one uses G-Proteins (Muscarinic). Nicotinic receptors are all exciatory, while Muscarinic receptors can be both excitatory and inhibitory depending on the subtype. Another difference being where they are found on the body. (Sympathetic vs Parasympathetic Nervous System)

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Class #8 Discussion Question

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1)    For the first step, you need to take on the role of a plant manager of a clothing manufacturing company located in your home country. A NGO vendor is sending an inspector to your facility to complete an audit of the working conditions for the employees at the location. Explain how you plan to handle the situation( try to research information online ). Provide a realistic description of how this would be managed in your country.

2) After that post, you then take on the role of the NGO auditor. Review the description from one of your classmates and discuss how you would handle an audit of a clothing manufacturer in that country. To get an idea of what’s involved in a social compliance audit, review the information provided at this link: https://www.intouch-quality.com/blog/the-3-most-common-types-of-factory-audits

All citations and references must be in correct APA formatting.

Cracking the code of life video reflection

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In this assignment you will watch a video about the Human Genome project. Describe your views on what you saw in a few of the segments shown.

Directions: For this assignment, you will watch the video Cracking the Code of Life
available at (or go to YouTube and search for “Cracking the Code of Life PBS Nova 2001”).

From the video, select a specific topic that you found surprising or interesting. Use any relevant resources to find out a little bit more about the topic and post your reaction to this on the message board. This should be around 3 paragraphs in length.

Post your assignment to the message board. Please do not upload files in case I am not able to open them.

Grading Rubric:

2 points – Identified a topic from the first half of the video

3 points – Presented external information relevant to the topic chosen

3 points – Thoroughly discussed the topic chosen

2 points – Completed on time


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Academy of Healing Arts Week 4 Nonverbal Communication and Behavior Paper

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no plagiarize, spell check, and check your grammar. Please use the 8 reference below. Be mindful of grammar.

This final paper preparation assignment will require the following:

  • State your topic choice for the Final Paper and explain why you chose it. (1 paragraph) – Non Verbal Communication
  • Provide a brief summary of what you plan to research about your topic. For example, in-depth paper might require regarding the pros and cons of INFJ MBTI personality type in groups compared to ISTJ personality types in groups, while an in-breadth topic might examine 16 MBTI personality types interacting in groups. (1 paragraph)
  • Explain what you hope to learn through the experience. (1 paragraph)
  • Compile an annotated bibliography, which will consist of no fewer than eight scholarly resources that are less than 6 years old, with the exception that you may include no more than two older articles that are widely recognized as seminal or classic works. Review the following guidelines regarding how to create an annotated bibliography in APA style, 6th edition:

References

Kádár, Magor E, PhD, habil. (2017). Introduction to profiling: The process of reading of nonverbal signs. Journal of Media Research, 10(1), 70-87. Retrieved from https://search-proquest-com.proxy-library.ashford.edu/docview/1929685850?accountid=32521

Künecke, J., Wilhelm, O., & Sommer, W. (2017). Emotion recognition in nonverbal face-to-face communication. Journal of Nonverbal Behavior, 41(3), 221-238. doi:http://dx.doi.org.proxy-library.ashford.edu/10.100…

Marono, A., Clarke, D. D., Navarro, J., & Keatley, D. A. (2018). A sequence analysis of nonverbal behaviour and deception. Journal of Police and Criminal Psychology, 33(2), 109-117. doi:http://dx.doi.org.proxy-library.ashford.edu/10.100…

Rotar, C., PhD. (2013). Nonverbal communication. Journal of Media Research, 6(1), 71-72. Retrieved from https://search-proquest-com.proxy-library.ashford….

Soukup, P. A., S.J. (2019). Nonverbal communication. Communication Research Trends, 38(1), 3-47. Retrieved from https://search-proquest-com.proxy-library.ashford….

Talley, L., & Temple, S. (2015). How leaders influence followers through the use of nonverbal communication. Leadership & Organization Development Journal, 36(1), 69-80. Retrieved from https://search-proquest-com.proxy-library.ashford….

Tecau, A. S., & Tescasiu, B. (2015). Nonverbal communication in the focus-group.Bulletin of the Transilvania University of Brasov.Economic Sciences.Series V, 8(2), 119-124. Retrieved from https://search-proquest-com.proxy-library.ashford.edu/docview/1768395572?accountid=32521

Vegrichtová, B. (2018). Nonverbal communication of prison subculture through criminal tattoo symbols. Academic and Applied Research in Military and Public Management Science, 17(3), 179-186. Retrieved from https://search-proquest-com.proxy-library.ashford….

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