NURS6640 WU Week 5 Anxiolytic Therapy & PTSD Treatment

Week 5: Anxiolytic Therapy & PTSD Treatment

“I’m no longer at the mercy of my PTSD, and I would not be here today had I not had the proper diagnosis and treatment. It’s never too late to seek help.”

—P.K. Philips, PTSD patient

For individuals suffering from posttraumatic stress disorder (PTSD) and other anxiety disorders, everyday life can be a constant challenge. Clients requiring anxiolytic therapy may present with anxiousness, depression, substance abuse issues, and even physical symptoms related to cardiovascular, respiratory, and gastrointestinal ailments. As a psychiatric mental health nurse practitioner, you must be prepared to address the many needs of individuals seeking treatment for PTSD and other anxiety disorders.

This week, as you study anxiolytic therapies and PTSD treatments, you examine the assessment and treatment of clients with PTSD and other anxiety disorders. You also explore ethical and legal implications of these therapies.

Photo Credit: [shironosov]/[iStock / Getty Images Plus]/Getty Images


Assignment: Assessing and Treating Clients With Anxiety Disorders

Common symptoms of anxiety disorders include chest pains, shortness of breath, and other physical symptoms that may be mistaken for a heart attack or other physical ailment. These manifestations often prompt clients to seek care from their primary care providers or emergency departments. Once it is determined that there is no organic basis for these symptoms, clients are typically referred to a psychiatric mental health practitioner for anxiolytic therapy. For this Assignment, as you examine the client case study in this week’s Learning Resources, consider how you might assess and treat clients presenting with anxiety disorders.

Learning Objectives

Students will:
  • Assess client factors and history to develop personalized plans of anxiolytic therapy for clients
  • Analyze factors that influence pharmacokinetic and pharmacodynamic processes in clients requiring anxiolytic therapy
  • Evaluate efficacy of treatment plans
  • Analyze ethical and legal implications related to prescribing anxiolytic therapy to clients across the lifespan

Learning Resources

Note: To access this week’s required library resources, please click on the link to the Course Readings List, found in the
Course Materials section of your Syllabus.

Required Readings

Note: All Stahl resources can be accessed through the Walden Library using this link. This link will take you to a log-in page for the Walden Library. Once you log into the library, the Stahl website will appear.

Stahl, S. M. (2013).
Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press.

To access the following chapters, click on the
Essential Psychopharmacology, 4th ed tab on the Stahl Online website and select the appropriate chapter. Be sure to read all sections on the left navigation bar for each chapter.

  • Chapter 9, “Anxiety Disorder and Anxiolytics”

Stahl, S. M., & Grady, M. (2010).
Stahl’s illustrated anxiety, stress, and PTSD. New York, NY: Cambridge University Press.

To access the following chapters, click on the
Illustrated Guides tab and then the
Anxiety, Stress, and PTSD tab.

  • Chapter 4, “First-Line Medications for PTSD”
  • Chapter 5, “Second-Line, Adjunct, and Investigational Medications for PTSD”

Strawn, J. R., Wehry, A. M., DelBello, M. P., Rynn, M. A., & Strakowski, S. (2012). Establishing the neurobiologic basis of treatment in children and adolescents with generalized anxiety disorder.
Depression and Anxiety, 29(4), 328–-339. doi:10.1002/da.21913

Note: Retrieved from Walden Library databases.

Hamilton, M. (1959). Hamilton Anxiety Rating Scale.
Psyctests, doi:10.1037/t02824-0

Note: Retrieved from Walden Library databases.

Required Media

Laureate Education. (2016b).
Case study: A middle-aged Caucasian man with anxiety [Interactive media file]. Baltimore, MD: Author.

Note: This case study will serve as the foundation for this week’s Assignment.

Optional Resources

Lupi, M., Martinotti, G., Acciavatti, T., Pettorruso, M., Brunetti, M., Santacroce, R., & … Di Giannantonio, M. (2014). Pharmacological treatments in gambling disorder: A qualitative review.
Biomed Research International, 2014. doi:10.1155/2014/537306

To prepare for this Assignment:

  • Review this week’s Learning Resources. Consider how to assess and treat clients requiring anxiolytic therapy.

The Assignment

Examine Case Study: A Middle-Aged Caucasian Man With Anxiety. You will be asked to make three decisions concerning the medication to prescribe to this client. Be sure to consider factors that might impact the client’s pharmacokinetic and pharmacodynamic processes.

At each decision point stop to complete the following:

  • Decision #1
    • Which decision did you select?
    • Why did you select this decision? Support your response with evidence and references to the Learning Resources.
    • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.
    • Explain any difference between what you expected to achieve with Decision #1 and the results of the decision. Why were they different?
  • Decision #2
    • Why did you select this decision? Support your response with evidence and references to the Learning Resources.
    • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.
    • Explain any difference between what you expected to achieve with Decision #2 and the results of the decision. Why were they different?
  • Decision #3
    • Why did you select this decision? Support your response with evidence and references to the Learning Resources.
    • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources.
    • Explain any difference between what you expected to achieve with Decision #3 and the results of the decision. Why were they different?

Also include how ethical considerations might impact your treatment plan and communication with clients.

Note: Support your rationale with a minimum of three academic resources. While you may use the course text to support your rationale, it will not count toward the resource requirement.

CASE STUDY

Generalized Anxiety Disorder
Middle-Aged White Male With Anxiety

Middle aged male

BACKGROUND INFORMATION

The client is a 46-year-old white male who works as a welder at a local steel fabrication factory. He presents today after being referred by his PCP after a trip to the emergency room in which he felt he was having a heart attack. He stated that he felt chest tightness, shortness of breath, and feeling of impending doom. He does have some mild hypertension (which is treated with low sodium diet) and is about 15 lbs. overweight. He had his tonsils removed when he was 8 years old, but his medical history since that time has been unremarkable. Myocardial infarction was ruled out in the ER and his EKG was normal. Remainder of physical exam was WNL.

He admits that he still has problems with tightness in the chest and episodes of shortness of breath- he now terms these “anxiety attacks.” He will also report occasional feelings of impending doom, and the need to “run” or “escape” from wherever he is at.

In your office, he confesses to occasional use of ETOH to combat worries about work. He admits to consuming about 3-4 beers/night. Although he is single, he is attempting to care for aging parents in his home. He reports that the management at his place of employment is harsh, and he fears for his job. You administer the HAM-A, which yields a score of 26.

Client has never been on any type of psychotropic medication.

MENTAL STATUS EXAM

The client is alert, oriented to person, place, time, and event. He is appropriately dressed. Speech is clear, coherent, and goal-directed. Client’s self-reported mood is “bleh” and he does endorse feeling “nervous”. Affect is somewhat blunted, but does brighten several times throughout the clinical interview. Affect broad. Client denies visual or auditory hallucinations, no overt delusional or paranoid thought processes readily apparent. Judgment is grossly intact, as is insight. He denies suicidal or homicidal ideation.

The PMHNP administers the Hamilton Anxiety Rating Scale (HAM-A) which yields a score of 26.

Diagnosis: Generalized anxiety disorder

RESOURCES

§ Hamilton, M. (1959). Hamilton Anxiety Rating Scale. Psyctests, doi:10.1037/t02824-0

Decision Point One

Select what the PMHNP should do:

Begin Zoloft 50 mg po daily

Begin Imipramine 25 mg po BID

Begin Buspirone 10 mg po BID

Answer: Begin Zoloft 50 mg orally daily

Generalized Anxiety Disorder
Middle-Aged White Male With Anxiety

Asian girl

RESULTS OF DECISION POINT ONE

  • Client returns to clinic in four weeks
  • Client informs you that he has no tightness in chest, or shortness of breath
  • Client states that he noticed decreased worries about work over the past 4 or 5 days
  • HAM-A score has decreased to 18 (partial response)

Decision Point Two

Select what the PMHNP should do next:

Increase dose to 75 mg orally daily

Increase dose to 100 mg orally daily

No change in drug/dose at this time

ANSWER Increase dose to 75 mg orally daily

Asian girl

RESULTS OF DECISION POINT TWO

  • Client returns to clinic in four weeks
  • Client reports an even further reduction in his symptoms
  • HAM-A score has now decreased to 10. At this point- continue current dose (61% reduction in symptoms)



Decision Point Three

Select what the PMHNP should do next:

Maintain current dose

Increase current dose of medication to 100 mg orally daily

Add augmentation agent such as BuSpar (buspirone)


Generalized Anxiety Disorder
Middle-Aged White Male With Anxiety

Asian girl

Decision Point One

Begin Zoloft 50 mg orally daily

RESULTS OF DECISION POINT ONE

  • Client returns to clinic in four weeks
  • Client informs you that he has no tightness in chest, or shortness of breath
  • Client states that he noticed decreased worries about work over the past 4 or 5 days
  • HAM-A score has decreased to 18 (partial response)

Decision Point Two

Increase dose to 75 mg orally daily

RESULTS OF DECISION POINT TWO

  • Client returns to clinic in four weeks
  • Client reports an even further reduction in his symptoms
  • HAM-A score has now decreased to 10. At this point- continue current dose (61% reduction in symptoms)

Decision Point Three

Maintain current dose

Guidance to Student

At this point, it may be appropriate to continue client at the current dose. It is clear that the client is having a good response (as evidenced by greater than a 50% reduction in symptoms) and the client is currently not experiencing any side effects, the current dose can be maintained for 12 weeks to evaluate full effect of drug. Increasing drug at this point may yield a further decrease in symptoms, but may also increase the risk of side effects. This is a decision that the PMHNP should discuss with the client. Nothing in the client’s case tells us that we should consider adding an augmentation agent at this point as the client is demonstrating response to the drug. Avoid polypharmacy unless symptoms cannot be managed by a single drug.

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Long term care/geriatric pharma-medical liaison specialty pharmacy The essay has to be 5 paragraph and about 3 or 4 page long.

Long term care/geriatric

pharma-medical liaison

specialty pharmacy

The essay has to be 5 paragraph and about 3 or 4 page long. first paragraph has to be the introduction about the three topics i gave above, and the next three paragraph talking about the three topics and the last paragraph conclusion. It has to be in APA format. Also put references and use the trusted website such as .org or .gov etc.

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Analysis Writing

3 paragraphs for specific reading
follow the rubric 
top sentence, evidence sentence and conclusion sentence
NO 1, 2 , 4 in reading documents
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Basic information for this currency pair EUR/USD # units required of the foreign currency1000000Direct pair (Y/N)Y # contracts needed to complete the…

Basic information for this currency pair

EUR/USD

# units required of the foreign currency1000000Direct pair (Y/N)Y

# contracts needed to complete the number of units8

BIdAskTransaction cost to trade one futures contract4Indirect price (beginning)N/AN/ATransaction cost to trade one options contract4Indirect price (end)N/AN/A

Direct price (beginning)1.2460001.2461002/2/2018DC1 date

Direct price (end)1.2410301.2411902/16/2018DC2 date

Pip converter (100 or 10000)

10000

Futures contract converter

1

Option price adjustment factor (1,100,10000)

1

1. Determine the percentage change in the currency’s value over the period studied

Initial spot

Final spot

% change

1.246050

1.241110

-0.40%

1a. Determine the percentage change in the futures contract over the period. Compare these two numbers.

Futures price (beg)Futures price (end)% change

1.248550

1.243950

-0.37%

Futures moved less than spot2. Assume that on the day of DC1, you had contracted to purchase imports, which would require you to pay 1 million units of the currency on the day of DC2. (Students selecting JPY must use 100,000,000 units for this question and for the following questions. Students selecting CNY must use 10,000,000 units for this question and for the following questions)

a. If you had hedged your position with a forward hedge, how many dollars would you have paid for the goods as of the end of the period?

Initial spot

Total cost

Fwd points

Unit cost

b. If you had hedged your position with a futures hedge, how many dollars would you have paid for the goods as of the end of the school term?

Final spot

Futures price (beg)

Total cost (before CME costs)

Futures price (end)

Unit cost

Total cost

c. If you had hedged your position with a call option hedge, how many dollars would you have paid for the payables as of the end of the period? Answer for the ITM, ATM and OTM call options. Please consider a cost of capital for the firm of 8% when you estimate the “total” premium paid and a 360 day convention.Please remember that quotes for option premiums and the strike price for the options differ among currencies. Some of them will require different adjustments (divide by 100, divide by 1 or divide by 10000). Be very careful when you calculate the total $ cost per unit

Final spot

Cost of capital

# days

ITMOption price (beg)

Total cost (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Total cost

ATMOption price (beg)

Total cost (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Total cost

OTMOption price (beg)

Total cost (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Total cost

d. Assume that you used a money market hedge at the beginning of the school term by borrowing USD at the LIBOR rate + 2%, converted into the foreign currency and invested at the LIBOR rate for the foreign currency to obtain enough money to pay for the account payable. How many dollars would you have to pay on the loan at the end of the school term?

Int rate

Time (in days)

Units of foreign currency needed

Total cost

Equivalent in USD to borrow

Loan amount + interest

Int rate

e. If you did not hedge, how many dollars would you have paid for the goods as of the end of the school term?

Final spot0.009062

Total cost

f. Fill out the table below 

Strategy used for payablesUnit costTotal dollar amount paid before commissionsTotal cost after considering CME fees

Forward hedge

Future hedge

Call options hedge (ITM)

Call options hedge (ATM)

Call options hedge (OTM)

Money market hedge

No hedge

Consider that trading one futures contract and trading one option contract costs you $7.50. In order to calculate the total commission you need to know how many contracts need to be traded. Please check the size of the futures contract and report the number of contracts required in the transaction.

3. This question connects with the forecast obtained in Fxstreet

Assume that the hedging decision depended on the forecast of the currency from FX street. If ALL analysts suggest that foreign currency is going up, then you want to hedge 100% of the payables. If ALL analysts suggest that foreign currency is going down, then you will play it conservatively and only hedge 25% of the exposure. You can choose to hedge a fraction of the amount based on the number (%) of analysts expecting an increase. Select the level and calculate the profit/loss for each hedging technique compared to the unhedged position (no hedge case).

Pair movement that hurts us

# analysts expecting such movementAmount to leave unhedged

# forecasts avaiable

Amount to hedge

Percentage to hedge

Cost of payables if left unhedged

Unhedged costHedged costTotalP/L

Forward hedge

Future hedge

Call options hedge (ITM)

Call options hedge (ATM)

Call options hedge (OTM)

Money market hedge

Which alternative was best in this case? Was your forecast useful? 

4. Assume that as of the beginning of the school term, you had contracted to sell exports, which would result in your receiving 1 million units of the foreign currency at the end of the school term. 

a. If you had hedged your position with a forward hedge, how many dollars would you have received for the goods as of the end of the school term?

Initial spot

Total revenue

Fwd points

Unit price

b. If you had hedged your position with a futures hedge, how many dollars would you have received for the goods as of the end of the school term?

Final spot

Futures price (beg)

Revenue (before CME costs)

Futures price (end)

Transaction costs

Unit price

Net revenue

c. If you had hedged your position with put options, how many dollars would you have received for the goods as of the end of the school term (account for the premium that you paid for the put option)? Answer for the ITM, ATM and OTM put options. Please consider a cost of capital for the firm of 8% when you estimate the “total” premium paid.Please remember that quotes for option premiums and the strike price for the options differ among currencies. Some of them will require different adjustments (divide by 100, divide by 1000 or divide by 10000) Be very careful when you calculate the total $ received per unit

Final spot

Cost of capital

# days

ITMOption price (beg)

Revenue (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Net revenue

ATMOption price (beg)

Revenue (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Net revenue

OTMOption price (beg)

Revenue (before CME costs)

Total premium

Option price (end)

Transaction costs

Unit cost (before commission)

Net revenue

d. Assume that you used a money market hedge at the beginning of the school term by borrowing foreign currency at the LIBOR rate + 3%, converted into USD and invested in the business at an annual rate of 8%. How many dollars would you “receive” at the end of the school term?

Int rate

Time (in days)

Units of foreign currency received

PV of revenue

Equivalent in USD to deposit

Amount received + “interest”

Int rate

e. If you did not hedge, how many dollars would you have received for the goods as of the end of the school term?

Final spot0.009060

Total revenue

f. Fill out the table below 

Strategy used for receivablesUnit priceTotal dollar amount receivedAmount received after CME costs

Forward hedge

Futures hedge

Put options hedge (ITM)

Put options hedge (ATM)

Put options hedge (OTM)

Money market hedge

No hedge

Consider that trading one futures contract and trading one option contract costs you $7.50. In order to calculate the total commission you need to know how many contracts need to be traded. Please check the size of the futures contract and report the number of contracts required in the transaction.

5. This question also connects with the FXstreet forecasts and the hedging decision depends on the number of analysts projecting an adverse movement.

If ALL analysts think the foreign currency is going up, then you want to hedge the lowest amount possible of the receivables, which is 25% If the forecasts suggest the foreign currency is going down, then you will definitely want to hedge 100% of the exposure. You can vary your amount to hedge based on the number (%) of analysts expecting an adverse movement. Select the hedging level and calculate the profit/loss for each hedging technique. Compare to the unhedged position (no hedge case) and determine what strategy was the best.

Pair movement that hurts us

# analysts expecting such movementAmount to leave unhedged

# forecasts avaiable

Amount to hedge

Percentage to hedge

Amount received if left unhedged

Unhedged revenueHedged revenueTotalP/L

Forward hedge

Future hedge

Put options hedge (ITM)

Put options hedge (ATM)

Put options hedge (OTM)

Money market hedge

Value created

Which alternative was best in this case? Was your forecast useful?

6. What have you learned about the different hedging methods? Compare MM hedge and forward hedge. Compare forward hedge and futures hedge. Compare options and futures. Which is easier to use? Which is riskier? Which has a higher initial cost?

 

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