Correlation of Anxiety & Asthma

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Hello, I need to change my research paper into PICO format. I need the following
1. PICO Question
2. Literature Review that answers & supports PICO question

The paper may need a lot of editing I am content with Chpt I and Chpt II (Introduction & Literature review). What needs work is Chpt III. I have attached a draft and a syllabus. The syllabus is a guideline to how the paper ought to be written.

metal toxicity on brain

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Literature review about the metal toxicity in brain, please include just these metal, (nickel, iron, Aluminium, zinc)
provide information about nickel toxicity on new born baby (does it make any modification for the DNA and does it affect boys and girls differently)
How do all metal get inside the brain and pass the blood brain barrier, does it bind to any Low molecular compound (what are they and how to bind them) or just bind to  transferrin in the blood.

please be specific to brain and the side effect of metal on brain provide some studies from the literature that support that and please make sure all references are from high impact paper and new
regards     

communication and technology

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please read the midterm prompt carefully answer each question with around 750 words and use all the sources that I provided including class slides and extra readings

you must reference lecture slides and readings in ur response thank you

for question 1 there is no extra materials just google and reference properly

thank you

DB4- 556

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Students will utilize the article Raising Capital: Equity v. Debt to complete this weeks discussion.

Students will discuss their understanding of the article and argue how raising capital is beneficial or detrimental to organizations.

The purpose of our discussion will offer an opportunity for students to discuss research findings of case study analysis with classmates and to gain a better understanding of course material. Students will be required to post about their understanding of the article.