Based on the above scenario, please develop an appropriate clinical question including the use of electrical stimulation. Please utilize the PICO formatting chart for question development found within this packet.

  1. Part One: Based on the above scenario, please develop an appropriate clinical question including the use of electrical stimulation. Please utilize the PICO formatting chart for question development found within this packet.
  2. Part Two: Conduct a literature search based upon the clinical question you created. Please include a detailed layout of your search including database utilized, Boolean search terms, how you narrowed results, etc. From the search, identify two articles that you feel will best guide you in this early stage of inquiry. The two articles do not need to match the exact clinical question, but should be relevant and provide insight to help in your decision making process.
  3. Part Three: Critique the two articles you attained using the format on the article critique pages of this packet.
  4. Part Four: In paragraph form, propose the outcomes that you believe could result from the plan developed by you and your preceptor when considering the articles you retrieved and assessed. A discussion of support for your clinical decision (or lack thereof) in the articles should be included. (This portion does not need to exceed one page)

Investigate the feasibility of a controlled-release acamprosate formulation and design an appropriate delivery system.

Background: Acamprosate is a generic drug used in the treatment of alcohol dependence. It is taken long-term (up to 12 months) after alcohol cessation to maintain abstinence. The poor oral bioavailability (~10%) and rapid elimination from the blood stream (half-life ~3 h) requires that acamprosate be administered orally at a relatively high dose (1.3 g/day) three times per day. The frequent dosing, along with behavioral issues associated with alcoholism, make non-compliance a serious concern. A controlled-release formulation that provides acamprosate at a constant rate for a prolonged time with a single parenteral injection could alleviate non-compliance.

Objective: The goals of the project are to investigate the feasibility of a controlled-release acamprosate formulation and design an appropriate delivery system. The delivery system must employ microspheres comprising PLGA 50/50 and should provide acamprosate at a near-constant rate of 130 mg/day for either 30, 60 or 90 days. Microspheres should be no less than 10 µm and no more than 80 µm in diameter.

The effective diffusivity of acamprosate in PLGA 50/50 is a function of polymer molecular weight according to the empirical power law: D(MW) = 5×1011·MW-1.634

Deliverables: Your report will consist of two main components.

  1. Market analysis. Evaluate and define the potential market for a controlled-release acamprosate formulation. Possible components of your analysis include the market size and potential market share, market outlook, proposed pricing, possible competitors on the market, technological or intellectual property barriers, and regulatory concerns.

Which one of the following is a strong, narrow cord of fibrous tissue that attaches muscle to bone?

Paper , Order, or Assignment Requirements

Exam: 084089RR Anatomy and Physiology

  1. Which one of the following is a strong, narrow cord of fibrous tissue that attaches muscle to bone?
  2. Tendon
  3. Ligament
  4. Phalanx
  5. Fascia
  1. The _______ is responsible for closing the airway to the lungs when one swallows.
  2. pharynx
  3. epiglottis
  4. larynx
  5. glottis
  1. Which one of the following statements about colds is false?
  2. Colds result from contact with other affected people.
  3. Colds are caused by bacteria.
  4. Chicken soup and antibiotics work equally well as treatment for colds.
  5. There’s no immunity to colds.
  1. The cardiovascular system consists of
  2. blood, blood vessels, and the heart.
  3. blood, blood vessels, the heart, lymph, lymph vessels, and lymphatic tissues.
  4. the heart, blood vessels, and lymph vessels.
  5. the heart and coronary arteries.
  1. The most complicated part of the brain is the
  2. brain stem.
  3. cerebellum.
  4. thalamus.
  5. cerebrum.
  1. The inner ear works with which brain structure to maintain equilibrium and balance?
  2. Medulla oblongata
  3. Hypothalamus
  4. Pons
  5. Cerebellum
  1. What is blood serum?
  2. Plasma with a clotting factor removed
  3. Fluid remaining after plasma is removed from whole blood
  4. Clear, yellowish fluid in which blood cells are suspended
  5. Whole blood
  1. The _______, which is situated beneath the pharynx, is responsible for producing vocal sounds.
  2. thalamus
  3. epiglottis
  4. larynx
  5. tongue
  1. In osteoporosis, the bones are soft and weak because
  2. there’s infection of the bone marrow.
  3. old tissue isn’t replaced quickly enough.
  4. the dead bone separates from the good bone.
  5. there’s too much calcium and phosphorus.
  1. What is bradycardia?
  2. Pain referred to the arm during a heart attack
  3. A blood vessel conveying blood to the arm
  4. Abnormally rapid heartbeat
  5. Abnormally slow heartbeat
  1. All of the following are factors in upper respiratory diseases except
  2. allergens.
  3. lowered body temperature.
  4. viruses.
  5. bacteria.
  1. The condition often called the “silent killer” is also known as
  2. hypertension.
  3. arteriosclerosis.
  4. coronary artery disease.
  5. anemia.
  1. Which of the following are degenerative illnesses?
  2. Chondrodynia and sternotomy
  3. Rheumatoid arthritis and muscular dystrophy
  4. Cardiac arrest and pulmonary thrombosis
  5. Dehydration and polydipsia
  1. Which of the following represents average blood pressure?
  2. 80/120
  3. 100/60
  4. Between 60 and 100
  5. 120/80
  1. What portion of the brain controls respiration?
  2. Medulla oblongata
  3. Pituitary gland
  4. Midbrain
  5. Cerebellum
  1. The period of relaxation in the cardiac cycle is
  2. depolarization.
  3. diastole.
  4. asystole.
  5. systole.
  1. Which of the following statements is not correct?
  2. Sensory nerves are efferent nerves.
  3. Nerves are made of sensory and/or motor fibers.
  4. The medulla oblongata connects the spinal cord to the rest of the brain.
  5. There are 12 pairs of cranial nerves.
  1. Which term indicates a “true” heart attack?
  2. Myocardial infarction
  3. Congestive heart failure
  4. Cardiac arrest
  5. Angina pectoris
  1. Bronchogenic carcinoma is cancer of the
  2. brain.
  3. lungs.
  4. throat.
  5. skin.
  1. Which of the following choices is a common symptom of anemia?
  2. Fatigue
  3. Fever
  4. Swollen lymph nodes
  5. Sore throat

Exam: 084088RR – Medical Terminology

  1. The meaning of analysis is
  2. absence of whole.
  3. to dissect.
  4. a cutting apart.
  5. a separating into parts.
  1. Which one of the following choices is a combining form, not a prefix or suffix?
  2. PATHO
  3. OPSY
  4. CENTESIS
  5. RETRO
  1. Which one of the following prefixes means “through”?
  2. “Pro”
  3. “Peri”
  4. “Pre”
  5. “Per”
  1. Which one of the following choices would be the ending of a term indicating the surgical removal of a

body part?

  1. “Ectomy”
  2. “Cision”
  3. “Itis”
  4. “Osis”
  1. Individuals with high blood pressure are often prescribed _______ by their physicians.
  2. hypoglycemics
  3. hypolipidemics
  4. antihyperlipidemics
  5. antihypertensives
  1. The organs of the abdominal cavity are called
  2. viscera.
  3. mediastinal.
  4. pleural.
  5. fascia.
  1. _______ are often used to prevent nausea and vomiting.
  2. Keratolytics
  3. Antitussives
  4. Antihistamines
  5. Antiemetics
  1. _______ are typically used to block pain.
  2. Anesthetics
  3. Antipruritics
  4. Anticoagulants
  5. Analgesics
  1. A patient lying horizontally on his or her belly is in the _______ position.
  2. prone
  3. laterally recumbent
  4. recumbent
  5. supine
  1. Your little toe is _______ to your torso.
  2. proximal
  3. lateral
  4. superior
  5. medial
  1. Which one of the following choices best describes a cell?
  2. A specialized body part composed of tissues
  3. Any complex living being, plant or animal
  4. The smallest “living” structure in the body
  5. A structure in the cytoplasm
  1. The pelvic cavity houses the
  2. brain and pituitary gland.
  3. urinary and reproductive organs.
  4. heart and lungs.
  5. major organs of digestion.
  1. In medical terminology, a _______ generally turns a word into a diagnosis or medical procedure.
  2. root
  3. suffix
  4. prefix
  5. combining form
  1. Which one of the following words is related to the axial skeleton?
  2. Brachial
  3. Metacarpal
  4. Patella
  5. Cranium
  1. A physician whose specialty is to diagnose and treat diseases and disorders involving the bones, joints,

and muscles is called a/an

  1. gerontologist.
  2. oncologist.
  3. orthopedist.
  4. chiropractor.
  1. The word parts -ac, -al, -ary, and -ic are all
  2. prefixes that function as prepositions.
  3. adjective suffixes meaning “pertaining to.”
  4. noun suffixes indicating procedures.
  5. pseudosuffixes formed from roots.
  1. The correct order for analyzing the parts of medical terms is
  2. prefix, root, suffix.
  3. root, suffix, prefix.
  4. suffix, root, prefix.
  5. suffix, prefix, root.
  1. The _______ is an axial body part.
  2. phalanx
  3. neck
  4. carpus
  5. tarsus
  1. What is the prefix meaning “excessive, above”?
  2. HYPOB.

-HYPO

  1. -HYPER
  2. HYPER
  3. Which one of the following suffixes means “inflammation”?
  4. -ITIS
  5. -DYNIA
  6. -OSIS
  7. -EMIA

THE PATHOPHYSIOLOGY OF DISEASE

Assignment 2: The Pathophysiology of Disorders

During the last 5 weeks, you have explored various body systems: neurological, cardiovascular, respiratory, and hematological. These four systems work together along with other body systems to complete a myriad of functions. For this reason, when disorders occur within one body system, it can create potentially devastating effects throughout the entire body. For instance, Parkinson’s disease is a disorder of the central nervous system, yet its alterations actually affect multiple body systems from the cardiovascular system to the gastrointestinal system. In this Assignment, you examine alterations associated with disorders, as well as the impact of the alterations on multiple body systems. To Prepare From the list below, select a disorder of interest to you: Alzheimer’s disease Asthma in children Chronic obstructive pulmonary disease (COPD) Congestive heart failure Hepatic disease (liver disease) Hypertension Hyperthyroidism and hypothyroidism Seizures Sepsis Identify alterations associated with your selected disorder. Consider the pathophysiology of the alterations. Think about how these alterations produce pathophysiological changes in at least two body systems. Reflect on how patient factors such as genetics, gender, ethnicity, age, and behavior might impact the pathophysiology of the alterations you identified, as well as the diagnosis and treatment of your selected disorder.  Review the “Mind maps—Dementia, Endocarditis, and Gastro-oesophageal Reflux Disease (GERD)” media in the Week 2 Learning Resources. Use the examples in the media as a guide to construct a mind map for the disorder you selected. Consider the epidemiology and clinical presentation of your selected disorder. To Complete Develop a 5- to 10-slide PowerPoint presentation that addresses the following: Describe your selected disorder, as well as associated alterations. Explain the pathophysiology of the alterations, including changes that occur in at least two body systems. Explain how genetics, gender, ethnicity, age, and behavior might impact the pathophysiology of the alterations you identified, as well as diagnosis and treatment of your selected disorder. Construct a mind map for the disorder you selected. Include the epidemiology, pathophysiology of alterations, risk factors, and clinical presentation, as well as the diagnosis and treatment of the disorder.